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KMID : 0043319940170050375
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Archives of Pharmacal Research
1994 Volume.17 No. 5 p.375 ~ p.377
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Antitumor Triterpense from Medicinal Plants
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Ryu Shi-Yong
Choi Sang-Un
Lee Seung-Ho
Lee Chong-Ock
No Zae-Sung
Ahn Jong-Woong
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Abstract
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Thirteen kinds of naturally occurring or derivatised thiterpenes, reported to have an antitumoral property, were reinvestigated on the basis of their direct cytotoxicity or the inhibitory activity on cell growth against five kinds of cultured human tumor cells, i.e., A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT15, in vitro. Ursonic acid III, betulinic acid VIII, betulonic acid X and glycrrhetinic acid XI were exhibitied a marked inhibition on cell growth.
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KEYWORD
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Triterpene, Antitumor, Betulinic acid, Betulonic acid, Ursonic acid, Glycyrrhetinic acid
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